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| miRNA调控破骨细胞分化研究进展 |
| Research progress in miRNA regulation of osteoclast differentiation |
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| DOI：10.3969/j.issn.1006.7108.2015.11.022 |
| 中文关键词: miRNA RANK 破骨细胞 骨质疏松症 |
| 英文关键词:miRNA RANK Osteoclast Osteoporosis |
| 基金项目:国家自然基金资助项目（81473692);康缘中医药科技创新与奖励基金项目（HZ1004KY) |
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| 中文摘要: |
| 随着miRNA的发现，其生理、病理作用逐渐被认识,在骨代谢方面,miRNA在破骨细胞的分化中扮演重要角色,本文将对近3年miRNA与破骨细胞分化的研究进行总结，阐述正常机体RANK通路中的miRNA,以及骨代谢疾病状态下改变的 miRNA,探讨miRNA在骨质疏松症中的作用,从细胞分子水平揭示骨质疏松症发病机制，并讨论miRNA相关制剂在骨质疏松症治疗方面的应用前景。 |
| 英文摘要: |
| With the discovery of microRNAs, their physiological and pathological role has been gradually known. In terms of bone metabolism, miRNA plays an important role in osteoclast differentiation. miRNA as a mediator in RANK pathway of osteoclast differentiation, can modulate many factors that influence the process rather than directly induce differentiation of osteoclast precursors. In this article we summarize the research about osteoclast differentiation in recent 3 years, explore miRNAs in normal RANK pathway in the body, and discuss the change of miRNAs in bone metabolic diseases to explore the role of miRNAs in osteoporosis. We reveal the pathogenesis of osteoporosis at cellular and molecular level, and discuss the application prospect of miRNA-related compounds in treatment of osteoporosis. |
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