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| 从脾肾论治骨质疏松症的神经-内分泌-免疫网络平衡机制 |
| NEI regulation mechanism of osteoporosis from spleen and kidney theory |
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| DOI：10.3969/j.issn.1006.7108.2015.11.027 |
| 中文关键词: 骨质疏松症；神经内分泌免疫网络（NEI) 脾肾同治；机制 |
| 英文关键词:Osteoporosis Nerve-endocrine-immune network (NEI) Simultaneous treatment of spleen and kidney Mechanism |
| 基金项目:国家自然科学基金项目（81360554);甘肃省自然科学基金计划（1506RJZA048 );甘肃省财政厅基本科研业务课题(BH2010-428);甘肃省中药现代制造工程研究院项目（YWW- 2015049) |
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| 中文摘要: |
| NEI网络调控秉承现代医学“元素中心论”建立,而中医理论秉承“系统中心论”建立，两者均强调机体的整体性和时空性特点，各种激素、细胞因子、神经递质等信使不仅是神经、内分泌、免疫三大系统的“共同语言”，同时也是中西医交融的结合点或共通点。在骨质疏松症的发生演变过程中，NEI网络对骨代谢的调控机制与其“脾肾同病、骨枯髓空、骨肉不相亲”的病机特点存在诸多联系，或者说后者是NEI网络微观信息的最终表达。鉴于此,本文就骨质疏松（骨痿）的病因病机及治则方药结合NEI网络对骨代谢的调控平衡机制做一综述，旨在为中医药防治原发性骨质疏松症提供客观的分子生物学依据。 |
| 英文摘要: |
| NEI network regulation is established according to central element theory of the modem medicine, but the theory of traditional Chinese medicine (TCM) is established according to system theory. Both emphasize body integrity and time and space features. All kinds of hormones, cytokines, and neurotransmitter messengers are not only the common language among nerve, endocrine, and immune system, but also the interact point of TCM and Western Medicine. During the occurrence and development of osteoporosis, there are many links between regulation of NEI network on bone metabolism and the TCM pathogenesis of spleen and kidney deficiency, marrow exhausted to bone withered, and disharmony between bone and muscle. In another word, the latter is the ultimate expression of NEI micro information. In view of this, this article reviews the mechanism of NEI network balance in the treatment of osteoporosis from the spleen and kidney theory, in order to provide an objective molecular biology basis of TCM in the prevention and treatment of primary osteoporosis (bone impotent). |
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