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| 骨质疏松治疗新靶点 |
| New therapeutic targets of osteoporosis |
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| DOI： |
| 中文关键词: 骨质疏松 发病机制 信号通路 治疗靶点 |
| 英文关键词:Osteoporosis Pathogenesis Signal pathways Therapeutic targets． |
| 基金项目: |
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| 中文摘要: |
| 随着社会的进步，生活水平的提高及人口老龄化时代的到来，骨质疏松发病率逐年增长并逐渐成为影响人们生活质量的慢性疾病之一。传统的骨质疏松治疗药物目前尚不能降低此疾病骨折的发生风险、不能有效提高骨密度及减轻疼痛等不适。如今，随着人们对骨质疏松发病机制的进一步探讨，参与骨质疏松发病的 OPG/ＲANKL/ＲANK、Wnt/β 连环蛋白信号通路、Sclerostin、CathepsinK 等信号分子逐步发现，并有望成为骨质疏松治疗的新靶点。 |
| 英文摘要: |
| With the development of our society，the improvement of living standard，and the arrival of the era of population aging，the incidence of osteoporosis increases year by year and gradually becomes one of the chronic diseases that affect people＇s live． At present，however，traditional anti-osteoporosis drugs can not reduce fracture risk of this disease，and can not effectively improve bone mineral density as well as relieve pain and discomfort． With the further exploration of the pathogenesis of osteoporosis，signal pathways such as OPG/ＲANKL/ＲANK，Wnt，sclerostin as well as cathepsin K，have been discovered in the development of the osteoporosis，which may be the novel therapeutic targets of osteoporosis in the future． |
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