中国骨质疏松杂志

地塞米松磷酸钠注射液在预防唑来膦酸注射液急性期反应中的价值

An evaluation of the effects of dexamethasone sodium phosphate injection in preventing acute-phase reaction of zoledronic acid injection in elder osteoporotic women

DOI：10.3969/j.issn.1006-7108.2016.10.019

中文关键词: 唑来膦酸地塞米松骨质疏松症急性期反应

英文关键词:Zoledronic acid Dexamethasone Osteoporosis Adverse-phase reaction

基金项目:浙江省医药卫生平台重点资助项目（2016ZDA002）；浙江省人民医院优秀青年人员科研启动基金（zry2015C002）

作者	单位
边平达1 寿张轩2 王珏1 应奇峰1 陈锦平1 *	1．浙江省人民医院望江山院区骨质疏松诊疗中心，浙江杭州 310024 2．浙江省人民医院药学部，浙江杭州 310014

摘要点击次数: 1270

全文下载次数: 653

中文摘要:

目的为了探讨地塞米松磷酸钠注射液在减少老年女性骨质疏松症（OP）患者静脉滴注唑来膦酸注射液后急性期反应（APR）发生中的价值。方法把68例老年女性OP患者，随机分成2组，其中1组在静脉滴注唑来膦酸注射液5mg前静脉推注地塞米松磷酸钠注射液5mg，然后比较两组患者72 h内在发热、流感样症状、肌痛、头痛头晕、失眠、恶心呕吐等APR发生率上差异。结果两组患者72 h内在发热、流感样症状、肌痛、头痛头晕、失眠、恶心呕吐等症状发生率上的差异无统计学意义（P ＞0.05）。结论静脉推注地塞米松磷酸钠注射液，不能降低老年女性OP患者静脉滴注唑来膦酸注射液后APR的发生率。

英文摘要:

Objective To evaluate the effects of dexamethasone sodium phosphate injection as a preventive procedure against acute-phase reaction (APR) of zoledronic acid injection in elder osteoporotic women. Methods A total of 68 elder osteoporotic women were randomized to either standard treatment group (n = 34 , zoledronic acid injection, 5mg, intravenous infusion) or dexamethasone group (n = 34, dexamethasone sodium phosphate injection 5 mg, push intravenous injection ,and zoledronic acid injection, 5mg, intravenous infusion). APR (≤72h after infusion), including pyrexia, influenza-like symptoms, myalgia, headache, swirl, insomnia, nausea and vomiting, etc. were compared between the two groups. Results There were no significant differences in APR between the standard treatment group and dexamethasone group (P>0.05). Conclusions Dexamethasone sodium phosphate injection could not to prevent against APR of zoledronic acid injection in osteoporotic women.

查看全文查看/发表评论下载PDF阅读器

关闭