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| MiRNA对成骨分化调控及骨质疏松发生的研究进展 |
| Research progress in the role of miRNA in regulation of osteoblastic differentiation and occurrence of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.01.027 |
| 中文关键词: 微小RNA 成骨分化 骨代谢 骨质疏松 |
| 英文关键词:miRNA Osteoblastic differentiation Bone metabolism Osteoporosis |
| 基金项目: |
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| 中文摘要: |
| 微小RNA（microRNA，miRNA）是一类具有调控功能的非编码RNA，其主要起转录后的调控作用，在生物信号调节网络中扮演着重要的角色。miRNA与成骨分化，骨质新生，骨改建等过程密切相关，miRNA表达异常可导致骨质疏松等一系列骨代谢相关疾病。鉴于miRNA在骨代谢调控中的重要作用，本文就miRNA在细胞成骨分化及其与骨质疏松发病机制的研究进行综述，以期为骨代谢相关疾病的治疗提供新的方向。 |
| 英文摘要: |
| MicroRNAs are a class of non-coding RNAs possessing regulatory function. They regulate gene expression in posttranscriptional way and play a vital role in the regulation network of biological signals. MiRNAs are closely related to osteoblastic differentiation, bone regeneration and reconstruction. Aberrant expression of miRNA results in a series of bone metabolism-related diseases, such as osteoporosis. Due to the crucial role of miRNA in the regulation of bone metabolism, this review mainly focuses on the functions of miRNA in the process of osteoblastic differentiation and pathogenesis of osteoporosis, which may provide new directions for the treatment of bone metabolism-related diseases. |
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