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| lncRNA对骨质疏松骨代谢相关信号通路影响的研究进展 |
| Advances on the effects of lncRNA on bone metabolism related signaling pathways in osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.04.026 |
| 中文关键词: 长链非编码RNA 骨质疏松 骨代谢 信号通路 |
| 英文关键词:lncRNA Osteoporosis Bone metabolism Signaling pathway |
| 基金项目:甘肃省中医药管理局2017立项课题（GZK-2017-18）；甘肃省重点中医药现代制药工程研究院自立项目（YWW-2015049） |
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| 中文摘要: |
| 长链非编码RNA(long non-coding RNA,lncRNA)参与了多种生物学过程，在基因表达如转录调控、表观遗传修饰及蛋白翻译后修饰等机制中发挥重要作用，若它们缺乏则会导致蛋白质编码能力的缺失，失调的lncRNA与骨质疏松密切相关。作为骨质疏松(osteoporosis, OP)骨代谢过程中的生物标志物，lncRNA调控骨代谢相关信号通路的作用机制复杂，随着表观遗传学的发展，lncRNA将为OP诊断、治疗及判断预后提供新的靶向目标。本文将从lncRNA与成骨细胞分化相关信号通路、与破骨细胞分化相关信号通路、与钙相关信号通路三个方面对近年来lncRNA与骨质疏松症骨代谢相关信号通路的研究进行综述。 |
| 英文摘要: |
| lncRNA (long non-coding RNAs) is involved in a variety of biological processes and plays an important role in gene expression, such as transcriptional regulation, epigenetic modification and post-translational modification of proteins, which leads to the loss of protein-coding ability. The disorders of lncRNA are closely related to osteoporosis. lncRNA is a biomarker in the metabolic process of osteoporosis and the mechanism of lncRNA regulation of bone metabolism related signaling pathway is complex. With the development of epigenetics, lncRNA will provide a new target for the diagnosis, treatment and prognosis of osteoporosis. In this paper, we summarized the influence of lncRNA on bone metabolism from three aspects: the relationship between lncRNA and osteoblast differentiation-related signal pathway, the relationship between lncRNA and osteoclasts differentiation-related signal pathway, and the relationship between lncRNA and calcium-related signal pathway. |
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