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| 补肾中药对骨髓间充质干细胞成骨分化的作用研究 |
| Effect of tonifying kidney herbs on osteogenic differentiation of bone marrow mesenchymal stem cells |
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| DOI：10.3969/j.issn.1006-7108.2019.02.027 |
| 中文关键词: 补肾中药 骨髓间充质干细胞 成骨分化 增殖 |
| 英文关键词:traditional Chinese medicine bone marrow mesenchymal stem cells osteogenic differentiation proliferation |
| 基金项目:国家自然科学基金(81503477)；辽宁省自然科学基金（201602497）；辽宁省教育厅一般项目（L201630） |
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| 中文摘要: |
| 骨髓间充质干细胞作为骨损伤后，骨修复、重建的种子细胞，越来越成为骨组织工程学中的研究热点。骨修复、重建的关键核心是如何能够提高骨髓间充质干细胞的高效增殖和成骨定向分化。以“肾藏精，主骨，生髓”的中医理论为依据，同时实验和临床也证实，补肾中药可以有效地促进骨髓间充质干细胞增殖、以及定向成骨分化。为骨损伤之后的修复和重建提供新的治疗途径。本文就近年补肾中药促进骨髓间充质干细胞成骨分化的研究做一综述。 |
| 英文摘要: |
| bone marrow mesenchymal stem cells (MSCs), as seed cells for bone repair and reconstruction after bone injury, have become a hot research topic in bone tissue engineering. The key of bone repair and reconstruction is how to improve the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Based on the traditional Chinese medicine theory of kidney storing essence, hosting bone and regenerating marrow, and the basic research and clinical practice, the kidney tonifying Chinese medicine can effectively promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. It provides a new treatment for repair and reconstruction after bone injury. This paper reviews the recent studies on the effect of tonifying kidney herbs on osteogenic differentiation by bone marrow mesenchymal stem cells. |
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