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| Wnt/β-catenin信号通路在补肾中药靶向治疗骨质疏松症中应用的研究进展 |
| Progress in the application of Wnt/β-catenin signaling pathway in the treatment of osteoporosis with Bushen Chinese herbs |
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| DOI：10.3969/j.issn.1006-7108.2019.04.027 |
| 中文关键词: 骨质疏松 通路 中药 靶向 进展 |
| 英文关键词:osteoporosis pathway traditional Chinese medicine targeting general situation |
| 基金项目:国家自然科学基金（地区）（81860864）；兰州市科技局社会发展项目（2016-3-102）；甘肃省属科研院所基础条件建设专项（18JR2TA016）；国家中医药管理局中医临床研究基地业务建设专项（JDZX2015080）；甘肃省省级引导科技创新发展专项资金项目；甘肃省卫健委十三五重点专科培育项目 |
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| 中文摘要: |
| 骨质疏松症是以骨质量降低、脆性增加为主要病理特征的全身代谢性骨病，其发病受多种因素的影响。随着我国人口老龄化加速，骨质疏松症发病率明显上升，其严重的并发症及较高的治疗费用给患者及社会带来严重的负担。近年来随着分子生物学的发展，对信号通路蛋白及基因的研究不断深入，发现Wnt/β-catenin通路在骨形成中发挥着重要的作用，本文将基于Wnt/β-catenin信号通路在骨质疏松症的发生及中药靶向治疗骨质疏松的研究概况方面做一综述，旨在为骨质疏松症的发病机制及精准靶向治疗提供一定的参考，为中药多靶点治疗骨质疏松症的独特优势提供新思路。 |
| 英文摘要: |
| Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass and increased brittleness, and its onset is affected by many factors. With the accelerated aging in the Chinese population, the incidence of osteoporosis has risen significantly, and its severe complications and high treatment costs have brought serious burdens to patients and the society. In recent years, with the development of molecular biology, the research on signaling pathway proteins and genes has been advanced, and it has been found that the Wnt/β-catenin pathway plays an important role in bone formation. This article reviewed the research progress of Wnt/β-catenin signaling pathway in the pathogenesis of osteoporosis and the targeted treatment of osteoporosis with traditional Chinese medicine, with the aim of providing certain references for the pathogenesis of osteoporosis and precise targeted therapy, and new ideas for exerting the unique advantages of traditional Chinese medicine of multi-target treatment of osteoporosis. |
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