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| Wnt/β-catenin信号通路在脊柱小关节骨性关节炎中的作用 |
| The role of Wnt/β-catenin signaling pathway in spinal facet joint osteoarthritis |
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| DOI：10.3969/j.issn.1006-7108.2021.08.025 |
| 中文关键词: Wnt/β-catenin信号通路 骨性关节炎 脊柱小关节骨性关节炎 抑制剂 |
| 英文关键词:Wnt/β-catenin signaling osteoarthritis facet joint osteoarthritis inhibitor |
| 基金项目:国家自然科学基金（81860406）；广西自然科学基金（2018JJA140082） |
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| 中文摘要: |
| 脊柱小关节骨性关节炎是由多种因素导致脊柱小关节的关节软骨发生损伤及退变的骨性关节炎。近来研究显示，Wnt/β-catenin信号通路在脊柱小关节骨性关节炎的发生发展过程中发挥着重要的作用，合适的胞内Wnt/β-catenin表达水平是影响临床表型的重要因素。针对Wnt/β-catenin信号通路的抑制剂、条件性激活/敲除的研究，有助于研究人员进一步了解Wnt/β-catenin信号通路在脊柱小关节骨性关节炎发病机制中的作用。本文将对Wnt/β-catenin信号通路及其在骨性关节炎、特别是脊柱小关节骨性关节炎中的最新研究结果和进展进行综述，并对未来的研究提出展望。 |
| 英文摘要: |
| The facet joint osteoarthritis is a kind of osteoarthritis which is caused by injured and degraded facet joint articular cartilage due to many factors. Nearly study shows, Wnt/β-catenin signaling plays an important role in the occurrence and development of facet joint osteoarthritis, and appropriate intracellular expression level of Wnt/β-catenin signaling is an important factor to clinical phenotype. The study about the inhibitor and conditional activation/knock out of Wnt/β-catenin signaling can help us further explore the role of Wnt/β-catenin signaling in pathogenesis of facet joint osteoarthritis. This article reviews the latest study results and progress of Wnt/β-catenin signaling in osteoarthritis, especially in facet joint osteoarthritis and had a prospect for further research. |
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